Article

Strelka2: Fast and accurate variant calling for clinical sequencing applications

2017-09-23

Abstract excerpt

We describe Strelka2 ( https://github.com/Illumina/strelka ), an open-source small variant calling method for clinical germline and somatic sequencing applications. Strelka2 introduces a novel mixture-model based estimation of indel error parameters from each sample, an efficient tiered haplotype modeling strategy and a normal sample contamination model to improve liquid tumor analysis. For both germline and soma...

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Literature Corpus work: 24a0f396-8ee0-5c24-8e9d-8829c3a08b3b
DOI: 10.1101/192872

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