Article

Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria

2019-06-26

Abstract excerpt

<h4>ABSTRACT</h4> LMNA encodes nuclear lamin A/C that tethers lamina-associated heterochromatin domains (LADs) to the nuclear periphery. Point mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown. We report that Ser22-phosphorylated Lamin A/C (pS22-Lamin A/C) was localized to the interior of the nucleus in human fibrobla...

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Literature Corpus work: aec618ca-c8d0-5f78-9a64-60450986b2c2
DOI: 10.1101/682260

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