Article
Lamin A involvement in ageing processes.
Ageing research reviews - 1 Sept 2020
Cenni Vittoria, Capanni Cristina, Mattioli Elisabetta, Schena Elisa, Squarzoni Stefano, Bacalini Maria Giulia, Garagnani Paolo, Salvioli Stefano, Franceschi Claudio, Lattanzi Giovanna
Abstract excerpt
Lamin A, a main constituent of the nuclear lamina, is the major splicing product of the LMNA gene, which also encodes lamin C, lamin A delta 10 and lamin C2. Involvement of lamin A in the ageing process became clear after the discovery that a group of progeroid syndromes, currently referred to as progeroid laminopathies, are caused by mutations in LMNA gene. Progeroid laminopathies include Hutchinson-Gilford...
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