Article

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome

2019-01-14

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a progeroid disease characterized by the early onset of some classically age-related phenotypes including arthritis, loss of body fat and hair and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein Lamin A (termed Progerin) and have previously been shown to exhibit prominent chromatin changes. Here, we identify ep...

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Literature Corpus work: 6f2bc16b-88b3-53bf-a9b3-d83096d395e5
DOI: 10.1101/520403

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