Article
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell - 1 Oct 2018
Mattioli Elisabetta, Andrenacci Davide, Garofalo Cecilia, Prencipe Sabino, Scotlandi Katia, Remondini Daniel, Gentilini Davide, Di Blasio Anna Maria, Valente Sergio, Scarano Emanuela, Cicchilitti Lucia, Piaggio Giulia, Mai Antonello, Lattanzi Giovanna
Abstract excerpt
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and premature aging, we found altered modulation of CDKN1A, encoding p21, upon oxidative stress induction, and accumulation of senescence markers during stress...
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