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Article

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.

Nucleus (Austin, Tex.) - 1 Jan 2015

Bercht Pfleghaar Katrin, Taimen Pekka, Butin-Israeli Veronika, Shimi Takeshi, Langer-Freitag Sabine, Markaki Yolanda, Goldman Anne E, Wehnert Manfred, Goldman Robert D

Abstract excerpt

More than 20 mutations in the gene encoding A-type lamins (LMNA) cause progeria, a rare premature aging disorder. The major pathognomonic hallmarks of progeria cells are seen as nuclear deformations or blebs that are related to the redistribution of A- and B-type lamins within the nuclear lamina. However, the functional significance of these progeria-associated blebs remains unknown. We have carried out an...

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Identifiers

PMID: 25738644
DOI: 10.1080/19491034.2015.1004256
PMCID: PMC4615727

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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