Article

A multiscale chromatin collapse underlies vascular pathology in Hutchinson–Gilford progeria syndrome

2025-12-15

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disorder driven by the accumulation of the lamin A variant, progerin, leading to severe vascular pathology. While epigenetic alterations are implicated, the spatiotemporal reorganization of the higher-order chromatin and its functional impact on vascular smooth muscle cell (VSMC) transcription remain poorly defined. Through an integrated,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38fddcb4-67bc-574b-8131-1177f128f487
DOI: 10.64898/2025.12.11.693713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multiscale chromatin collapse underlies vascular pathology in Hutchinson–Gilford progeria syndromeDOI 10.64898/2025.12.11.693713Read

Early Polycomb-target deregulations in Hutchinson-Gilford Progeria Syndrome revealed by heterochromatin analysisSemantic proximity Read

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria SyndromeSemantic proximity Read

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.Semantic proximity Read

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossificationSemantic proximity Read

Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeriaSemantic proximity Read

Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation.Semantic proximity Read

Vascular senescence in progeria: role of endothelial dysfunctionSemantic proximity Read

Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndromeSemantic proximity Read

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).Semantic proximity Read

Expansion <i>in situ</i> genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repressionSemantic proximity Read

Hutchinson-Gilford progeria syndrome through the lens of transcription.Semantic proximity Read

Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas.Semantic proximity Read