Article

Genetic Studies of Bone Diseases: Evidence for Involvement of DNA Damage Response Proteins in Bone Remodeling

2007-12-15

Abstract excerpt

Bone remodeling is carried out by bone marrow mesenchymal stem cell derived osteoblasts, which form the bones, and hematopoeitic stem cell derived osteoclasts, which absorb the bones. Their actions are coordinated in two ways: osteoblasts and their precursors synthesize and secrete cytokines such as RANKL and M-CSF to regulate osteoclastogenesis; bone resorption releases matrix associated TGF-β and BMPs to stimula...

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Literature Corpus work: ae80d7cd-486c-5a4c-aeda-aa7c0eb9e28d
DOI: 10.59566/ijbs.2007.3217

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