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Article

Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis

27 Apr 2006

Abstract excerpt

Atm is a Ser/Thr kinase involved in DNA damage response and is required for genome integrity and stem cell renewal. Here, we report an additional role for Atm in bone remodeling. Atm-/- mice showed reduced bone mass, especially at the trabecular bones, accompanied by a decrease in bone formation rate and defective differentiation of osteoblasts, but normal numbers of osteoprogenitor cells and osteoblasts. Atm...

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PMID: 16644862
DOI: 10.1093/hmg/ddl116

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