Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.

doi:10.1083/jcb.200508130

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Article

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.

The Journal of cell biology - 13 Mar 2006

Lengner Christopher J, Steinman Heather A, Gagnon James, Smith Thomas W, Henderson Janet E, Kream Barbara E, Stein Gary S, Lian Jane B, Jones Stephen N

Abstract excerpt

Mdm2 is required to negatively regulate p53 activity at the peri-implantation stage of early mouse development. However, the absolute requirement for Mdm2 throughout embryogenesis and in organogenesis is unknown. To explore Mdm2-p53 signaling in osteogenesis, Mdm2-conditional mice were bred with Col3.6-Cre-transgenic mice that express Cre recombinase in osteoblast lineage cells. Mdm2-conditional Col3.6-Cre mice...

Topics

Animals
Bone Development
Bone Neoplasms
Cell Differentiation
Cell Proliferation
Cell Transformation, Neoplastic
Cells, Cultured
Core Binding Factor Alpha 1 Subunit
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Mice

Mice, Transgenic

Osteoblasts

Osteosarcoma

Proto-Oncogene Proteins c-mdm2

Signal Transduction

Skeleton

Stem Cells

Source

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Identifiers

PMID: 16533949
DOI: 10.1083/jcb.200508130
PMCID: PMC2063734

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