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BCR/ABL, DNA damage and DNA repair: Implications for new treatment concepts

1 Jan 2008

Abstract excerpt

BCR/ABL fusion tyrosine kinase transforms hematopoietic stem cells causing chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). BCR/ABL regulates numerous proteins involved in apoptosis, proliferation and cell - cell or cell - extracellular matrix interactions. However, BCR/ABL also enhances DNA damage caused by endogenous reactive oxygen species and exogenous genotoxic treatment. In...

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PMID: 18398719
DOI: 10.1080/03093640701859089

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BCR/ABL, DNA damage and DNA repair: Implications for new treatment conceptsPMID 18398719Read ↗

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