Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 control of bone remodeling

29 Jun 2010

Abstract excerpt

Tumor suppressor p53 is a transcription regulator that displays anti-proliferation activities once activated by stress, in particular genotoxic stress. Recent mouse genetic studies revealed a critical role for p53 in bone remodeling, supported by both loss-of-function and gain-of function studies. p53 deficiency concurrently enhances proliferation and accelerates differentiation in mesenchymal stem cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and treatments
Share to Bone Metabolism and Diseases
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20589754
DOI: 10.1002/jcb.22749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 control of bone remodelingPMID 20589754Read ↗

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodelingSemantic proximity Read ↗

Genetic Studies of Bone Diseases: Evidence for Involvement of DNA Damage Response Proteins in Bone RemodelingSemantic proximity Read ↗

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.Semantic proximity Read ↗

p53 Loss Increases the Osteogenic Differentiation of Bone Marrow Stromal CellsSemantic proximity Read ↗

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasisSemantic proximity Read ↗

p53 plays a central role in the development of osteoporosisSemantic proximity Read ↗

Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cellsSemantic proximity Read ↗

Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesisSemantic proximity Read ↗

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseSemantic proximity Read ↗

The RUNX Family of Proteins, DNA Repair, and CancerSemantic proximity Read ↗

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent MannerSemantic proximity Read ↗

Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and OsteoporosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.