Article

Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophages

2021-01-22

Abstract excerpt

Genome-wide association studies have identified 3p21.31 as the main risk locus for severe disease in COVID-19 patients, although underlying biological mechanisms remain elusive. We performed a comprehensive epigenomic dissection of the 3p21.31 locus, identifying a CTCF-dependent tissue-specific 3D regulatory chromatin hub that controls the activity of several tissue-homing chemokine receptor (CCR) genes in monocyt...

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Literature Corpus work: ae77a3d5-a92a-58fb-8d6e-3f7af1fce7d9
DOI: 10.1101/2021.01.22.427813

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