Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19.

doi:10.3390/ijms22105372

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Article

Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19.

International journal of molecular sciences - 20 May 2021

Cantalupo Sueva, Lasorsa Vito Alessandro, Russo Roberta, Andolfo Immacolata, D'Alterio Giuseppe, Rosato Barbara Eleni, Frisso Giulia, Abete Pasquale, Cassese Gian Marco, Servillo Giuseppe, Gentile Ivan, Piscopo Carmelo, Della Monica Matteo, Fiorentino Giuseppe, Russo Giuseppe, Cerino Pellegrino, Buonerba Carlo, Pierri Biancamaria, Zollo Massimo, Iolascon Achille, Capasso Mario

Abstract excerpt

Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role in other infection diseases, we investigated if common noncoding and rare coding variants, affecting CCR5, can predispose to severe COVID-19. We combined single nucleotide polymorphisms (SNPs) that met the suggestive significance level (P ≤ 1 × 10-5) at...

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PMID: 34065289
DOI: 10.3390/ijms22105372
PMCID: PMC8161088

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