Back to search

Article

Integrative approach identifies <i>SLC6A20</i> and <i>CXCR6</i> as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

2021-04-13

Abstract excerpt

To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
95f2c525-806f-53a0-af1f-33e1044dacd5
DOI
10.1101/2021.04.09.21255184
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrative approach identifies <i>SLC6A20</i> and <i>CXCR6</i> as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locusDOI 10.1101/2021.04.09.21255184
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.Semantic proximity
Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19Semantic proximity
Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19.Semantic proximity
Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative AnalysesSemantic proximity
AncestryDNA COVID-19 Host Genetic Study Identifies Three Novel LociSemantic proximity
Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophagesSemantic proximity
Genome-wide association studies of COVID-19: Connecting the dotsSemantic proximity
Association of <i>CXCR6</i> with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulationSemantic proximity
Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19Semantic proximity
An integrated strategy to identify COVID-19 causal genes and characteristics represented by LRRC37A2.Semantic proximity
Canadian COVID-19 host genetics cohort replicates known severity associations.Semantic proximity
Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.Semantic proximity
Select a neighboring publication to make it the new centre.