Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

1 Dec 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe COVID-19 in some patients and mild COVID-19 in others. Dysfunctional innate immune responses have been identified to contribute to COVID-19 severity, but the key regulators are still unknown. Here, we present an integrative single-cell multi-omics analysis of peripheral blood mononuclear cells from hospitalized and convalescent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36474914
DOI: 10.1016/j.xgen.2022.100232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19PMID 36474914Read ↗

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.Semantic proximity Read ↗

Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophagesSemantic proximity Read ↗

Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patientsSemantic proximity Read ↗

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell typesSemantic proximity Read ↗

Human genetic variants associated with COVID-19 severity are enriched in immune and epithelium regulatory networksSemantic proximity Read ↗

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19Semantic proximity Read ↗

Single cell sequencing analysis uncovers genetics-influenced CD16+monocytes and memory CD8+T cells involved in severe COVID-19Semantic proximity Read ↗

Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell typesSemantic proximity Read ↗

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19.Semantic proximity Read ↗

Identification of reactive CpGs and RNA expression in early COVID-19 through <i>cis</i> -eQTM analysis reflecting disease severity and recoverySemantic proximity Read ↗

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.Semantic proximity Read ↗

GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.