Article

Common variants at 21q22.3 locus influence<i>MX1</i>gene expression and susceptibility to severe COVID-19

2020-12-20

Abstract excerpt

The COVID-19 disease, caused by the SARS-Cov-2, presents a heterogeneous clinical spectrum. The risk factors do not fully explain the wide spectrum of disease manifestations, so it is possible that genetic factors could account for novel insights into its pathogenesis. In our previous study, we hypothesized that common variants on chromosome 21, near TMPRSS2 and MX1 genes, may be genetic risk factors associated to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d684e494-1ffa-5794-9cf3-fe99026365d1
DOI: 10.1101/2020.12.18.20248470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Common variants at 21q22.3 locus influence<i>MX1</i>gene expression and susceptibility to severe COVID-19DOI 10.1101/2020.12.18.20248470Read

Common Variants at 21q22.3 Locus Influence <i>MX1</i> Gene Expression and Susceptibility to Severe COVID-19Semantic proximity Read

Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19Semantic proximity Read

Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and SusceptibilitySemantic proximity Read

ACE2, TMPRSS2, and TLR8 single-nucleotide polymorphisms are associated with a high risk of severe COVID-19 disease and deathSemantic proximity Read

Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.Semantic proximity Read

Host genetic factors determining COVID-19 susceptibility and severity.Semantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19.Semantic proximity Read

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibilitySemantic proximity Read

<i>TMPRSS2</i> variants and their susceptibility to COVID-19: focus in East Asian and European populationsSemantic proximity Read

Genetic predisposition in patients with severe COVID-19.Semantic proximity Read