Article

Towards the NMR solution Structure and the Dynamics of the C-terminal Region of APOL1 and its G1, G2 Variants with a Membrane Mimetic

2021-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Secreted apolipoprotein L1 (APOL1) is well known as an innate immune factor, protecting against African trypanosomiasis. The intracellular form has multiple functions, including regulating autophagy, intracellular vesicle trafficking, and ion channel activity. The APOL1 protein (G0) has two common variants (denoted G1 and G2) in the C-terminal region and are associated with a high risk of chroni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae6c468a-dba6-51c8-a359-ecb900e34b27
DOI: 10.1101/2021.03.16.435683

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Towards the NMR solution Structure and the Dynamics of the C-terminal Region of APOL1 and its G1, G2 Variants with a Membrane MimeticDOI 10.1101/2021.03.16.435683Read

The APOL1 variant p.N264K blocks ion flow by occluding a pore at the cell surfaceSemantic proximity Read

APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8Semantic proximity Read

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.Semantic proximity Read

Structure and Dynamics of Micelle-Associated Human Immunodeficiency Virus gp41 Fusion Domain <sup>,</sup>Semantic proximity Read

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and PodocytesSemantic proximity Read

ACIDIC BICELLES ARE A SUITABLE MEMBRANE MIMIC FOR STRUCTURAL STUDIES OF THE LASSA VIRUS FUSION DOMAINSemantic proximity Read

Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methodsSemantic proximity Read

Analytical methodology for unveiling the physical effect of detergents on the function of full-length membrane proteins using a single-molecule tracking systemSemantic proximity Read

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membraneSemantic proximity Read

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hcSemantic proximity Read

Renal disease factor APOL1: plasma membrane pools resist rapid turnoverSemantic proximity Read

Alpha1-antitrypsin deficiency--a model for conformational diseases.Semantic proximity Read