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Article

APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8

19 Jul 2017

Abstract excerpt

APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or APOL1 genotypes, suggesting that the kidney disease-associated variants dysregulate its function rather than its localization or abundance. Structural homology...

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PMID: 28724794
DOI: 10.1172/jci.insight.92581

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