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Structure and Dynamics of Micelle-Associated Human Immunodeficiency Virus gp41 Fusion Domain <sup>,</sup>

16 Nov 2005

Abstract excerpt

The N-terminal fusion domain of the HIV-1 gp41 envelope glycoprotein is responsible for initiating the fusion of viral and cellular membranes, leading to the subsequent infection of the host cell by HIV-1. We have investigated the backbone structure and dynamics of the 30 N-terminal residues of HIV-1 gp41 in membrane-mimicking environments using NMR spectroscopy and (15)N- and (15)N,(13)C,(2)H-labeled peptides....

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PMID: 16331977
DOI: 10.1021/bi051672a

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