APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

doi:10.1016/j.celrep.2020.02.064

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Article

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Cell reports - 17 Mar 2020

Uzureau Sophie, Lecordier Laurence, Uzureau Pierrick, Hennig Dorle, Graversen Jonas H, Homblé Fabrice, Mfutu Pepe Ekulu, Oliveira Arcolino Fanny, Ramos Ana Raquel, La Rovere Rita M, Luyten Tomas, Vermeersch Marjorie, Tebabi Patricia, Dieu Marc, Cuypers Bart, Deborggraeve Stijn, Rabant Marion, Legendre Christophe, Moestrup Søren K, Levtchenko Elena, Bultynck Geert, Erneux Christophe, Pérez-Morga David, Pays Etienne

Abstract excerpt

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticulum and Golgi membranes. We report that in podocytes, either APOL1 C-terminal helix truncation (APOL1Δ) or APOL3...

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Identifiers

PMID: 32187552
DOI: 10.1016/j.celrep.2020.02.064
PMCID: PMC7090385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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