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Article

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

6 Aug 2020

Abstract excerpt

Significance Statement Two variants of circulating APOL1, G1 and G2, protect against subspecies of Trypanosoma brucei infection, but concurrently confer a greater risk of CKD. Little is known about the topology of APOL1 in HDL particles or on the podocyte cells affected in kidney disease. Antibodies generated along the length of APOL1 revealed differences of the exposed domains between serum and podocyte surface...

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PMID: 32764138
DOI: 10.1681/asn.2019080830

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