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Article

Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study

13 Feb 2019

Abstract excerpt

BACKGROUND: Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic factor receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it is a promising therapeutic target for cardiometabolic diseases and anorexia/cachexia. Although many pharmaceutical companies are developing drugs...

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PMID: 30772304
DOI: 10.1016/j.ebiom.2019.02.021

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