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Genetically proxied growth differentiation factor 15 levels and body mass index

2021-01-17

Abstract excerpt

Growth-differentiation factor 15 (GDF15) is an inflammatory cytokine involved in energy homeostasis. Its circulating levels are acutely increased by the type 2 diabetes medication metformin, resulting in reduced appetite and weight loss. We identified a genetic variant at the GDF15 gene to proxy a small, lifelong increase in circulating GDF15 levels, and leveraged it in colocalization and Mendelian randomization a...

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Literature Corpus work
e989bbcd-74d4-5056-939f-9f5a4eee43bc
DOI
10.22541/au.161091413.31122882/v1
Open publication

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Genetically proxied growth differentiation factor 15 levels and body mass indexDOI 10.22541/au.161091413.31122882/v1
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