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Article

Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

2 Aug 2022

Abstract excerpt

Growth differentiation factor-15 (GDF15) is a stress response cytokine that is elevated in several cardiometabolic diseases and has attracted interest as a potential therapeutic target. To further explore the association of GDF15 with human disease, we conducted a broad study into the phenotypic and genetic correlates of GDF15 concentration in up to 14,099 individuals. Assessment of 772 traits across 6610...

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PMID: 35916366
DOI: 10.7554/elife.76272

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