Article

A loss-of-function variant in GFRAL associates with increased alcohol consumption in humans

2026-03-09

Abstract excerpt

Alcohol is an ancient and enduring component of the human diet, yet it is a dose-dependent cytotoxin and teratogen, raising the possibility that endogenous, state-dependent mechanisms constrain intake. Growth differentiation factor 15 (GDF15) is an endocrine hormone that rises during pregnancy—predominantly via secretion from blastocyst-derived placental trophoblasts into the maternal circulation—and is also induc...

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Literature Corpus work: 6c2307dd-5ca6-585b-bdc5-a3638d3a18be
DOI: 10.64898/2026.03.06.709997

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