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Article

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis.

The Journal of cell biology - 1 Dec 2008

Whyte Jacqueline, Bader Jason R, Tauhata Sinji B F, Raycroft Maurice, Hornick Jessica, Pfister K Kevin, Lane William S, Chan Gordon K, Hinchcliffe Edward H, Vaughan Patricia S, Vaughan Kevin T

Abstract excerpt

Cytoplasmic dynein functions at several sites during mitosis; however, the basis of targeting to each site remains unclear. Tandem mass spectrometry analysis of mitotic dynein revealed a phosphorylation site in the dynein intermediate chains (ICs) that mediates binding to kinetochores. IC phosphorylation directs binding to zw10 rather than dynactin, and this interaction is needed for kinetochore dynein...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19029334
DOI: 10.1083/jcb.200804114
PMCID: PMC2592828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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