Article

Differential responsesof pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

2023-02-10

Abstract excerpt

<h4>Background: </h4> Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for the expression of a subset of NF-κB-induced inflammatory genes which can be inhibited by the BET mimic JQ1+. We hypothesised that JQ1 + would supress TNF...

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Literature Corpus work: ae42bc2e-04e8-50d7-96d6-c71bb1a62d5f
DOI: 10.21203/rs.3.rs-2560986/v1

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