Article
JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.
Thorax - 1 Jun 2018
Milara Javier, Ballester Beatriz, Morell Anselm, Ortiz José L, Escrivá Juan, Fernández Estrella, Perez-Vizcaino Francisco, Cogolludo Angel, Pastor Enrique, Artigues Enrique, Morcillo Esteban, Cortijo Julio
Abstract excerpt
BACKGROUND: Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF mainly due to ventilation (V)/perfusion (Q) mismatching and oxygen desaturation. Janus kinase type 2 (JAK2) is a non-receptor tyrosine kinase activated by a broad spectrum of profibrotic and...
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