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Article

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension.

The European respiratory journal - 1 Oct 2016

Dabral Swati, Tian Xia, Kojonazarov Baktybek, Savai Rajkumar, Ghofrani Hossein Ardeschir, Weissmann Norbert, Florio Monica, Sun Jan, Jonigk Danny, Maegel Lavinia, Grimminger Friedrich, Seeger Werner, Savai Pullamsetti Soni, Schermuly Ralph Theo

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterised by excessive pulmonary vascular remodelling involving deregulated proliferation of cells in intima, media as well as adventitia. Pulmonary arterial endothelial cell (PAEC) hyperproliferation and survival underlies the endothelial pathobiology of the disease.The indispensable involvement of Notch1 in the arterial endothelial phenotype and angiogenesis provides...

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Source

Identifiers

PMID: 27471204
DOI: 10.1183/13993003.00773-2015

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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