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BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs

23 Apr 2020

Abstract excerpt

Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription. A third, less studied epigenetic pathway involves the reading of these specific histone marks once placed. The BETs (bromodomain and extraterminal-containing protein family), which includes BRD2, BRD3, and...

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PMID: 32324495
DOI: 10.1161/circresaha.120.315929

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