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Article

MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension

14 Oct 2022

Abstract excerpt

Background: Dysregulated BMP (bone morphogenetic protein) or TGF-β (transforming growth factor beta) signaling pathways are imperative in idiopathic and familial pulmonary arterial hypertension (PAH) as well as experimental pulmonary hypertension (PH) in rodent models. MED1 (mediator complex subunit 1) is a key transcriptional co-activator and KLF4 (Krüppel-like factor 4) is a master transcription factor in...

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PMID: 36252121
DOI: 10.1161/circresaha.122.321532

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