Article

Krüppel-like factor 2- induced microRNAs: implications for treatment of pulmonary hypertension

2019-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Flow-activated transcription factor Krüppel-like factor 2 (KLF2) signaling is compromised in pulmonary arterial hypertension (PAH). We aimed to identify KLF2-induced endothelium-protective exosomal microRNAs of potential therapeutic significance. Eight exosomal microRNAs elevated by KLF2 but reduced in PAH were transfected into human pulmonary artery endothelial cells. Of these, only miR-181a-5p...

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Literature Corpus work: 09adc274-f2d0-5772-ae87-1b62c8c60d95
DOI: 10.1101/583633

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