Article

Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in mice

2026-04-14

Abstract excerpt

<h4>SUMMARY</h4> Electroconvulsive therapy (ECT) is a highly effective treatment for several psychiatric disorders, though its biological mechanisms remain unclear. Its therapeutic action has traditionally been attributed to the generalized seizure ECT induces. However, this view is challenged by the recent finding that electroconvulsive stimulation (ECS) can trigger a cortical spreading depression (CSD). Because...

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Literature Corpus work: ae386c40-7673-5ed5-87df-498b359c0742
DOI: 10.64898/2026.04.14.718362

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