Article
Genetic fate mapping of type-1 stem cell-dependent increase in newborn hippocampal neurons after electroconvulsive seizures.
Hippocampus - 1 Dec 2013
Weber Tillmann, Baier Vera, Lentz Katharina, Herrmann Elke, Krumm Bertram, Sartorius Alexander, Kronenberg Golo, Bartsch Dusan
Abstract excerpt
Electroconvulsive therapy (ECT) is a uniquely effective treatment for major depressive disorder. An increase in hippocampal neurogenesis is implicated in the recovery from depression. We used an inducible genetic mouse model in which only GFAP-expressing stem-like cells (type-1 cells) and their progeny are selectively labeled with the reporter protein β-galactosidase to track the process of neurogenesis in the...
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