Article

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

2024-11-01

Abstract excerpt

Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and unresolved. Using optical neuroimaging of neural activity and hemodynamics in a mouse model of ECT, we demonstrated that a second brain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51c0a8fa-4421-5a16-8b44-62642c6d630c
DOI: 10.1101/2024.10.31.621357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humansDOI 10.1101/2024.10.31.621357Read

Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in miceSemantic proximity Read

Region-specific spreading depolarization drives aberrant post-ictal behaviorSemantic proximity Read

Seizure-associated spreading depression is a major feature of ictal events in two animal models of chronic epilepsySemantic proximity Read

Photothrombosis induced cortical stroke produces electrographic epileptic biomarkers in miceSemantic proximity Read

Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humansSemantic proximity Read

Central-positive complexes in ECT-induced seizures: Evidence for thalamocortical mechanismsSemantic proximity Read

A hyperthermic seizure unleashes a surge of spreading depolarizations in <i>Scn1a</i> deficient miceSemantic proximity Read

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.Semantic proximity Read

Control of brain state transitions with lightSemantic proximity Read

Epigenetic Effects of Electroconvulsive SeizuresSemantic proximity Read

Neurobiological mechanisms of ECT and TMS treatment in depression. Study protocol of a multimodal magnetic resonance investigationSemantic proximity Read

Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical NeurosolverSemantic proximity Read