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Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways

17 Mar 2004

Abstract excerpt

Electroconvulsive therapy (ECT) remains the treatment of choice for drug-resistant patients with depressive disorders, yet the mechanism for its efficacy remains unknown. Gene transcription changes were measured in the frontal cortex and hippocampus of rats subjected to sham seizures or to 1 or 10 electroconvulsive seizures (ECS), a model of ECT. Among the 3500-4400 RNA sequences detected in each sample, ECS...

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PMID: 15028759
DOI: 10.1523/jneurosci.5377-03.2004

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