Article

Closed-loop electrical stimulation to prevent focal epilepsy progression and long-term memory impairment

2024-02-12

Abstract excerpt

Interictal epileptiform discharges (IEDs) are ubiquitously expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes as most therapeutics target seizures. We show in a model of progressive hippocampal epilepsy that IEDs produce pathological oscillatory coupling which is associated with prolonged, hypersynchronous neural...

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Literature Corpus work: 9e2e1a2d-d5bd-5858-8a49-7d13d833bc07
DOI: 10.1101/2024.02.09.579660

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