Article

Signaling specificity and kinetics of the human metabotropic glutamate receptors

2023-07-26

Abstract excerpt

Metabotropic glutamate receptors (mGluRs) are obligate dimer G protein coupled receptors that can all function as homodimers. Here, each mGluR homodimer was examined for its G protein coupling profile using a BRET based assay that detects the interaction between a split YFP-tagged Gβ 1 γ 2 and a Nanoluc tagged free Gβ γ sensor, MAS-GRK3-ct-NLuc with 14 specific G⍺ proteins heterologously expressed, representing...

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Literature Corpus work: ae0fc242-57b2-5b95-a05e-229fedad0ee6
DOI: 10.1101/2023.07.24.550373

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