Article
Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2003
Poisik Olga V, Mannaioni Guido, Traynelis Stephen, Smith Yoland, Conn P Jeffrey
Abstract excerpt
Group I metabotropic glutamate receptors (mGluRs) 1 and 5 frequently colocalize in the same neurons throughout the CNS. Because both receptors can couple to the same effector systems, the purpose of their cellular coexpression remains unclear. Here, we report that group I mGluR1 and mGluR5 have distinct functional roles in type II neurons of the rat globus pallidus (GP). Type II GP neurons form a large population...
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