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Article

G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression.

Neuropharmacology - 1 May 2003

Sorensen Scott D, Conn P Jeffrey

Abstract excerpt

Metabotropic glutamate receptors (mGluR) serve important neuromodulatory roles at glutamatergic synapses to shape excitatory neurotransmission. Recent evidence indicates that the desensitization of mGluRs is an important determinant in regulating the functions of these receptors. The present results demonstrate that G protein-coupled receptor kinases (GRKs), which are known to regulate the desensitization of many...

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Source

Identifiers

PMID: 12681368
DOI: 10.1016/s0028-3908(03)00053-4

Genes

GRK2
GRK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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