Article
Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b.
Neuropharmacology - 1 Jul 1998
Hiltscher R, Seuwen K, Boddeke H W, Sommer B, Laurie D J
Abstract excerpt
Functional coupling of the human mGlu1 splice variants was examined by heterologous expression. In cells stably (CHO) or transiently (A9) expressing the hmGlu1d receptor. agonists elevated intracellular calcium with a rank order of potency typical of a group I mGlu receptor (quisqualate > L-gluta...
Topics
- Adenylate Cyclase Toxin
- Aequorin
- Alternative Splicing
- Amino Acid Sequence
- Animals
- CHO Cells
- Calcium
- Cell Line
- Cricetinae
- Cycloleucine
- Excitatory Amino Acid Agonists
- Genetic Variation
- Glutamic Acid
- Humans
- Inositol Phosphates
- Molecular Sequence Data
- Pertussis Toxin
- Polymerase Chain Reaction