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Article

An overview of DNA methylation-derived trait score methods and applications.

Genome biology - 16 Feb 2023

Nabais Marta F, Gadd Danni A, Hannon Eilis, Mill Jonathan, McRae Allan F, Wray Naomi R

Abstract excerpt

Microarray technology has been used to measure genome-wide DNA methylation in thousands of individuals. These studies typically test the associations between individual DNA methylation sites ("probes") and complex traits or diseases. The results can be used to generate methylation profile scores (MPS) to predict outcomes in independent data sets. Although there are many parallels between MPS and polygenic (risk)...

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Identifiers

PMID: 36797751
DOI: 10.1186/s13059-023-02855-7
PMCID: PMC9936670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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