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Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits.

Genetic epidemiology - 1 Dec 2022

Fryett James J, Morris Andrew P, Cordell Heather J

Abstract excerpt

As popularised by PrediXcan (and related methods), transcriptome-wide association studies (TWAS), in which gene expression is imputed from single-nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating the role of gene expression in complex traits. Like gene expression, DNA methylation is an important biological process and, being under genetic...

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PMID: 35930604
DOI: 10.1002/gepi.22496
PMCID: PMC9804820

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