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Article

Activation of TRESK channels by the inflammatory mediator lysophosphatidic acid balances nociceptive signalling.

Scientific reports - 30 Jul 2015

Kollert Sina, Dombert Benjamin, Döring Frank, Wischmeyer Erhard

Abstract excerpt

In dorsal root ganglia (DRG) neurons TRESK channels constitute a major current component of the standing outward current IKSO. A prominent physiological role of TRESK has been attributed to pain sensation. During inflammation mediators of pain e.g. lysophosphatidic acid (LPA) are released and modulate nociception. We demonstrate co-expression of TRESK and LPA receptors in DRG neurons. Heterologous expression of...

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Source

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Identifiers

PMID: 26224542
DOI: 10.1038/srep12548
PMCID: PMC4519772

Genes

LPA
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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