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Article

Impaired intracellular trafficking defines early Parkinson's disease

29 Jan 2015

Abstract excerpt

Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and represents a significant cost to individuals, carers, and ageing societies. It is defined at post-mortem by the loss of dopamine neurons in the substantia nigra together with the presence of Lewy bodies and Lewy neurites. We examine here the role of α-synuclein and other cellular transport proteins implicated in PD and how their...

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PMID: 25639775
DOI: 10.1016/j.tins.2014.12.009

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