Article

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon

2024-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Mucosal healing is associated with better clinical outcomes in patients with inflammatory bowel diseases (IBDs). Unresolved injury and inflammation, on the other hand, increases pathological fibrosis and the predisposition to cancer. Loss of Smad4, a tumor suppressor, is known to increase colitis-associated cancer in mouse models of chronic IBD. Since common biological processes are involved in...

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Literature Corpus work: add32772-c803-564c-9c9e-d1607009ed70
DOI: 10.1101/2024.03.08.578000

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