Article
Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.
Scientific reports - 9 Nov 2016
Lepage David, Bélanger Élise, Jones Christine, Tremblay Sarah, Allaire Joannie M, Bruneau Joannie, Asselin Claude, Perreault Nathalie, Menendez Alfredo, Gendron Fernand-Pierre, Boudreau Francois
Abstract excerpt
The intestinal epithelial barrier is critical to limit potential harmful consequences from exposure to deleterious luminal contents on the organism. Although this barrier is functionally important along the entire gut, specific regional regulatory mechanisms involved in the maintenance of this barrier are poorly defined. Herein, we identified Gata4 as a crucial regulator of barrier integrity in the mouse proximal...
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