Article

Neuropeptide Y deficiency in the bone marrow drives hematopoietic stem and progenitor cell aging

2026-02-20

Abstract excerpt

Aging-related blood disorders are linked to defects in the regenerative and multilineage differentiation ability of hematopoietic stem and progenitor cells (HSPCs). While remodeling of the bone marrow (BM) microenvironment where HSPCs reside is known to contribute to these age-associated defects, the underlying factors and mechanisms remain poorly defined. Here, we discovered that the age-related decline of the ne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adcd5bf1-d21c-5ec3-971e-178073a9ebf2
DOI: 10.64898/2026.02.20.706987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuropeptide Y deficiency in the bone marrow drives hematopoietic stem and progenitor cell agingDOI 10.64898/2026.02.20.706987Read

Tissue resident stem cells: till death do us partSemantic proximity Read

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological AgingSemantic proximity Read

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?Semantic proximity Read

Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.Semantic proximity Read

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.Semantic proximity Read

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systemsSemantic proximity Read

Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future PerspectivesSemantic proximity Read

Human hypothalamic neural stem cells transplantation ameliorates age-associated dysfunction through SNS/eNAMPT axis activation in aged miceSemantic proximity Read

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.Semantic proximity Read

Adult skull bone marrow is an expanding and resilient hematopoietic reservoirSemantic proximity Read

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell AgingSemantic proximity Read

MYB insufficiency disrupts proteostasis in hematopoietic stem cells leading to age-related neoplasiaSemantic proximity Read