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Article

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.

Journal of hematology & oncology - 23 Nov 2020

Zhang Lei, Mack Ryan, Breslin Peter, Zhang Jiwang

Abstract excerpt

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33228751
DOI: 10.1186/s13045-020-00994-z
PMCID: PMC7686726

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